Hepatic regeneration and growth factors

Hepatic regeneration and growth factors.

ANTONIO FRANCAVILLA. MO, PhD, LUIGI POLIMENO, PhD, MICHElE BARONE, MD, ALESSANDRO AZZARONE, MO, AND THOMAS E. STARZL, MO, PhD From the Department of Gastroenterology, University of Bari, Bari, Italy (A.F., L.P., M.B., A.A.), and the Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, and the Veterans Administration Medical Center, Pittsburgh, Pennsylvania (T...

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

During liver regeneration quiescent hepatocytes undergo one or two rounds of replication and then return to a nonproliferative state. Growth factors regulate this process by providing both stimulatory and inhibitory signals for cell proliferation. EGF, TGF alpha, and HGF stimulate DNA synthesis in hepatocytes in vivo and in culture but the sensitivity of cultured hepatocytes to the mitogenic ef...

Synthetic growth factors for bone regeneration Zeinab Tahmasebi Birgani BIOINORGANICS SYNTHETIC GROWTH FACTORS FOR BONE REGENERATION

Growth Factors and Transcription Factors in Liver Regeneration

Liver recapitulates the same size as before partial hepatectomy (PH). Once hepatectomized, tumor necrosis factor (TNF) a and interleukin (IL)-6 are secreted from non-parenchymal cells. The cytokines promotes hepatocyte proliferation via signal transducer and activator of transcription 3. Hepatocyte growth factor and epidermal growth factor are potent mitogen of hepatocytes. CCAAT/enhancer bindi...

Augmenter of liver regeneration: its place in the universe of hepatic growth factors.

As every school child knows, chameleons can regenerate a lost tail. Indeed, regrowth of appendages is a not uncommon phenomenon among other lower animals. In mammals, however, regenerative capacity is much more restricted. The special regenerative capability of the mammalian liver has been recognized over millennia, as epitomized by the ancient legend of Prometheus. The explanation for liver re...